MTOR Kinase Inhibitor AZD8055
Information
- Drug Name
- MTOR Kinase Inhibitor AZD8055
- Description
- Entry(CIViC)
- 3
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer |
MTOR p.Met2327Ile (p.M2327I) ( ENST00000361445.9, ENST00000703140.1 ) MTOR p.Met2327Ile (p.M2327I) ( ENST00000703140.1, ENST00000361445.9 ) |
D |
Predictive
|
Supports
|
Resistance | Somatic | 4 | 27279227 | Detail |
| breast cancer |
MTOR p.Ala2034Val (p.A2034V) ( ENST00000361445.9, ENST00000703140.1 ) MTOR p.Ala2034Val (p.A2034V) ( ENST00000361445.9, ENST00000703140.1 ) |
D |
Predictive
|
Does Not Support
|
Resistance | Somatic | 4 | 27279227 | Detail |
| cancer | HRAS MUTATION HRAS MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 26544513 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| MCF-7 breast cancer cell line was exposed to mTOR ... | MTOR |
MTOR p.Met2327Ile (p.M2327I) ( ENST00000361445.9, ENST00000703140.1 ) MTOR p.Met2327Ile (p.M2327I) ( ENST00000703140.1, ENST00000361445.9 ) |
Resitance or Non-Reponse | true | CIViC Evidence | detail |
| MCF-7 breast cancer cell line was exposed to mTOR ... | MTOR |
MTOR p.Ala2034Val (p.A2034V) ( ENST00000361445.9, ENST00000703140.1 ) MTOR p.Ala2034Val (p.A2034V) ( ENST00000361445.9, ENST00000703140.1 ) |
Resitance or Non-Reponse | false | CIViC Evidence | detail |
| A pre-clinical study in 10 solid cancer cell lines... | HRAS | HRAS MUTATION HRAS MUTATION | Sensitivity | true | CIViC Evidence | detail |